Alzheimer’s related memory loss linked to Neuroligin-1 protein

Cleveland Clinic identifies mechanism in Alzheimer’s-related memory loss — Study uncovers role of Neuroligin-1 protein – Cleveland Clinic researchers have identified a protein in the brain that plays a critical role in the memory loss seen in Alzheimer’s patients. The protein – Neuroligin-1 (NLGN1) – is known to be involved in memory formation; this is the first time it’s been linked to amyloid-associated memory loss.

High good and low bad cholesterol levels healthy for brain

High good and low bad cholesterol levels are healthy for the brain, too – High levels of “good” cholesterol and low levels of “bad” cholesterol are correlated with lower levels of the amyloid plaque deposition in the brain that is a hallmark of Alzheimer’s disease, UC Davis researchers have found.

Vitamin E may slow functional decline in Alzheimer’s Disease patients

Vitamin E May Delay Decline in Mild-to-Moderate Alzheimer’s Disease — Study Shows Benefit in Activities of Daily Living and Savings in Caregiver Time with Vitamin E – A new research suggests that alpha tocepherol, fat-soluble Vitamin E and antioxidant, may slow functional decline (problems with daily activities such as shopping, preparing meals, planning, and traveling) in patients with mild-to-moderate Alzheimer’s disease and decrease caregiver burden.

Concussions may be related to Alzheimer’s disease

Are concussions related to Alzheimer’s disease? – A history of concussion involving at least a momentary loss of consciousness may be related to the buildup of Alzheimer’s-associated plaques in the brain, revealed by researchers in Neurology, the medical journal of the American Academy of Neurology.

Regular physical activity in later life boosts healthy aging sevenfold

Regular physical activity in later life boosts likelihood of ‘healthy aging’ up to sevenfold — Helps stave off major ill health and dementia even for those getting started relatively late – It’s never too late to get physically active, with even those starting relatively late in life reaping significant health benefits, reveals researchers. Four years of sustained regular physical activity boosted the likelihood of healthy ageing sevenfold compared with consistent inactivity.

A good night’s rest may literally clear the mind

Brain may flush out toxins during sleep — NIH-funded study suggests sleep clears brain of damaging molecules associated with neurodegeneration – Using mice, researchers showed for the first time that the space between brain cells may increase during sleep, allowing the brain to flush out toxins that build up during waking hours. These results suggest a new role for sleep in health and disease.

Disrupting an antioxidant pathway prevents heart failure

Disrupting an antioxidant pathway prevents heart disease caused by reductive stress – Researchers have found that deficiency of an antioxidant response protein called nuclear erythroid-2 like factor-2 (Nrf2) delays or prevents hypertrophic cardiomyopathy, a type of a heart failure in which the heart muscle grows abnormally thick.

Endurance exercise improves brain health

Scientists identify protein linking exercise to brain health – A protein that is increased by endurance exercise has been isolated and given to non-exercising mice, in which it turned on genes that promote brain health and encourage the growth of new nerves involved in learning and memory.

Age Related Memory Loss is reversible

A Major Cause of Age-Related Memory Loss Identified — Study points to possible treatments and confirms distinction between memory loss due to aging and that of Alzheimer’s – The researchers have identified a protein-RbAp48-that, when increased in aged wild-type mice, improves memory back to that of young wild-type mice. They have found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible.

Parkinson’s Biomarker Test has prognostic and diagnostic value in Parkinson’s Disease

Comprehensive Parkinson’s Biomarker Test Has Prognostic and Diagnostic Value, Penn Medicine Team Reports — First Biomarker Results from Parkinson’s Progression Markers Initiative Detect Differences in Subtypes of Parkinson’s Disease – The first biomarker results reported from the Parkinson’s Progression Markers Initiative (PPMI), showing that a comprehensive test of protein biomarkers in spinal fluid have prognostic and diagnostic value in early stages of Parkinson’s disease.