Selective reporting of antidepressant trials may have adverse consequences

Evidence-based medicine is valuable to the extent that the evidence base is complete and unbiased. Selective publication of clinical trials ? and the outcomes within those trials ? can lead to unrealistic estimates of drug effectiveness and alter the apparent risk?benefit ratio. – Selective publication in reporting results of antidepressant trials exaggerates the effectiveness of the drugs, and may have adverse consequences for researchers, study participants, health care professionals, and patients, revealed in a new study.

Exercise may benefit older breast cancer survivors

An Oregon Health & Science University Cancer Institute study will evaluate the beneficial effects of aerobic exercise and resistance training for breast cancer survivors who are at least two years post-treatment with chemotherapy or radiation. – An Oregon Health & Science University Cancer Institute study is examining different forms of exercise for women older than 65 who have had breast cancer. Different exercises may benefit older breast cancer survivors.

Genetic testing can gauge prostate cancer risk

Five genetic variants and a family history accounted for almost half (46 percent) of prostate cancer patients. Researchers identified five genetic locations associated with risk of developing prostate cancer: three on chromosome 8q24, one on chromosome 17q12 and one on 17q24.3. – Genetic testing of DNA in a blood sample can determine which men are likely to develop prostate cancer, as five genetic variants previously associated with prostate cancer risk have a strong cumulative effect.

Genetically modified carrots provide more calcium for osteoporosis patients

Genetically modifying carrots to express increased levels of a gene that enables the transport of calcium across membranes of plant cells can make the vegetables a better source of calcium. – A specially developed carrot has been produced to help people absorb more calcium. Researchers studied the calcium intake of humans who ate the carrot and found a net increase in calcium absorption. Adding this carrot to the diet can help prevent such diseases as osteoporosis.

Fragile X syndrome affecting brain cells

Dr. Kimberly Huber investigated how Fragile X syndrome affects communication between cells in the hippocampus, a region of the brain that is involved in learning and memory. Fragile X syndrome is the most common cause of inherited mental retardation and the most common genetic cause of autism. – Researchers at UT Southwestern Medical Center are uncovering how brain cells are affected in Fragile X syndrome, the most common cause of inherited mental retardation and the most common genetic cause of autism.

AIDS drugs may prevent vaginal transmission of HIV

There are 33 million people infected with HIV. This study is a highly significant breakthrough because it offers proof-of-principle that pre-exposure prophylaxis with currently available anti-retroviral drugs can potentially prevent vaginal HIV transmission, empowering women throughout the world to protect themselves from this deadly disease. – Prescription drugs now used to treat human immunodeficiency virus infection in adults may prevent the vaginal transmission of HIV, researchers at UT Southwestern Medical Center have found.

Unified effort needed to save lives by increasing use of CPR

Quick initiation of CPR (Cardiopulmonary resuscitation), as well as providing high quality CPR, is crucial to survival from sudden cardiac arrest. – A unified effort by the public, educators and policymakers is needed to reduce deaths from sudden cardiac arrest by increasing the use and effectiveness of cardiopulmonary resuscitation (CPR), according to a new statement from the American Heart Association.

Vitamin D deficiency may increase heart disease risk

Vitamin D deficiency is associated with incident cardiovascular disease. Further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease. – The same vitamin D deficiency that can result in weak bones now has been associated with an increased risk of cardiovascular disease, Framingham Heart Study researchers report in Circulation: Journal of the American Heart Association.

Arthritis drug celecoxib can adversely affect heart rhythm

There has been much concern about the possibility of increased risk for heart attack and stroke in users of NSAID drugs, particularly COX-2 selective NSAIDs such as celecoxib. – COX-2 inhibitors like Celecoxib have come under scrutiny lately due to adverse cardiovascular side-effects stemming from COX-2 reduction. In both fruit fly and rat models, researchers reveal another adverse effect of Celecoxib; this drug can induce arrhythmia. More interestingly, this effect is independent of the COX-2 enzyme.

Bird flu alert in West Bengal, India

Health officials in India are concerned there may be a possible major bird-flu outbreak after nearly 20000 chickens died in the past week. – Death of poultry birds has been reported from parts of Birbhum and South Dinajpur districts of West Bengal, India.

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