Epidermolysis bullosa simplex

Epidermolysis bullosa simplex (EBS) is a disorder resulting from mutations in the genes encoding keratin 5 or keratin 14. Blister formation of EBS is within the basal keratinocyte of the epidermis. Sometimes EBS is called epidermolytic.

Sulforaphane in broccoli could treat genetic skin disorder

A recent paper presented at American Society for Cell Biology annual meeting highlighted that natural compound sulforaphane in broccoli could treat devastating genetic skin blistering disorder called epidermolysis bullosa simplex (EBS).
– The compound sulforaphane whose natural precursors are found at high levels in broccoli and other cruciferous vegetables has been hailed for its chemopreventive powers against cancer. Now sulforaphane has demonstrated new skills in treating a genetic skin blistering disorder called epidermolysis bullosa simplex (EBS), Pierre Coulombe and colleagues at the Johns Hopkins University School of Medicine in Baltimore report at the American Society for Cell Biology 47th Annual Meeting.

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