Genetic changes may lead to Barrett’s esophagus and esophageal cancer

Research discovers genetic link to Barrett’s esophagus, esophageal cancer — 5-year study identifies genes that predispose for BE/EAC – Mutations in three genes have been identified that are more prevalent in patients with esophageal cancer and Barrett esophagus, a premalignant metaplasia (change in cells or tissue) caused by chronic gastroesophageal reflux disease (GERD), according to preliminary research reported in the July 27 issue of JAMA.

Long term use of heartburn drugs linked to fractures

FDA: Possible Fracture Risk with High Dose, Long-term Use of Proton Pump Inhibitors — Labeling changes will include new safety information – The U.S. Food and Drug Administration warned consumers and health care professionals about a possible increased risk of fractures of the hip, wrist, and spine with high doses or long-term use of a class of medications called proton pump inhibitors.

Ulcer medicines may lead to infections and fractures

Studies document risks associated with common acid-suppressing medications – Proton pump inhibitors, medications that suppress acid in the stomach, appear to be associated with fractures in postmenopausal women and bacterial infections in many patients, and higher doses do not appear any more beneficial for treating bleeding ulcers.

Gastric ulcer medicines increase pneumonia risk in hospitals

Acid-suppressive medication use was associated with 30% increased odds of hospital-acquired pneumonia. – Hospitalized patients who receive acid-suppressive medications such as a proton-pump inhibitor have a 30 percent increased odds of developing pneumonia while in the hospital, according to a study in the May 27 issue of JAMA.

Impact of Gastroesophageal reflux disease on survival

In this population-based study, reflux symptoms were not associated with worse survival. The vast majority of heartburn sufferers can be reassured of the benign nature of their condition. – Gastroesophageal reflux disease (GERD), often known as acid reflux, is a common problem that has been associated with cancers, asthma, recurrent aspiration and pulmonary fibrosis. A new study published in The American Journal of Gastroenterology examines whether GERD sufferers may have shorter lifespans than those without the disease.

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