Pazopanib better than sunitinib in advanced kidney cancer

Pazopanib shows better quality-of-life in advanced kidney cancer – Two oral targeted drugs — Pazopanib (Votrient) and sunitinib (Sutent) — approved for metastatic kidney cancer worked equally well, but one proved superior in tolerability, the safety profile and many measures of quality of life favored pazopanib.

Gene is mutated in 1 in 3 patients with kidney cancer

Research provides new kidney cancer clues — Gene is mutated in 1 in 3 patients with common form of renal cancer – Researchers have identified a gene that is mutated in one in three patients with the most common form of renal cancer. The identification of a frequently mutated gene will provide new insights into the biology of the disease.

Preventive surgeries better in breast or ovarian cancer patients

For some women, preventive mastectomies pay off — Study shows women with BRCA1 and BRCA2 genetic mutations significantly reduce their risk of breast and ovarian cancer with preventive surgeries – A long-term study of women with a genetic predisposition for breast or ovarian cancer showed that those who elected major preventive surgeries had a significantly reduced risk of those cancers.

Stem cell protein LIN28 offers a new cancer target

LIN28, which maintains cell ‘stemness,’ is abundant in advanced cancers and transforms cells to cancerous state – A protein abundant in embryonic stem cells is now shown to be important in cancer, and offers a possible new target for drug development, report researchers from the Stem Cell Program at Children’s Hospital Boston.

New cancer gene UTX identified

Getting down to cancer basics — Cancer mutations in the heart of gene regulation. – Researchers have identified a new cancer gene – one that is common to many cancers and affects the most basic regulation of our genes.

Smoking during pregnancy increases cancer risk in child

Smoking during pregnancy increases a child?s likelihood of developing cancer. – New research by the Cancer Institute NSW has provided the strongest indication yet that smoking during pregnancy increases a child’s likelihood of developing cancer.

Nexavar approved for patients with inoperable liver cancer

Anticancer drug Nexavar raised survival period in inoperable hepatocellular carcinoma patients suffering from this kind of liver cancer. – The U.S. Food and Drug Administration has approved Nexavar (sorafenib) for use in patients with a form of liver cancer known as hepatocellular carcinoma, when the cancer is inoperable. Nexavar was originally approved in 2005 for the treatment of patients with advanced renal cell carcinoma, a form of kidney cancer.

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