Gender may play role in kidney transplant

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There are more chances of kidney rejection in a woman who gets a kidney from a male donor, revealed by Swiss researchers in a research paper published in the current issue of the medical journal The Lancet from UK.

Researchers at University Hospital Basel, Switzerland analyzed records of nearly 2 lacs people in Europe. Researchers did a retrospective cohort study between 1985 and 2004 in 195516 recipients of allografts from deceased donors. They used multivariate statistical methods to compare graft survival and death-censored graft survival rates for female and male donor kidneys in female and male recipients at 1 and 10 years.

Graft loss was more common with kidneys from female donors than with kidneys from male donors after both one year and 10 years. Female recipients had a lower rate of graft failure between the end of the first year and the end of the 10th year.

Researchers concluded that H-Y minor histocompatibility affects human kidney transplantation, and these findings imply that future studies and decisions about organ donations should take gender into consideration.

The study was funded by the Swiss National Research Foundation; University of Heidelberg, Germany; European Leukemia Net.

The study was published in this week’s issue of The Lancet.

Source: Lancet, UK

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