Individuals who have higher levels of education and who are more impaired by Parkinson’s disease appear to require treatment for their symptoms earlier than do other patients, revealed by researchers.
The new study will appear in the September print issue of Archives of Neurology.
Parkinson’s disease is a chronic progressive neurodegenerative disease that leads to significant morbidity, disability and increased likelihood of institutionalization.
In view of the potential for short-term and long-term drug complications, symptomatic treatment is customarily delayed in Parkinson’s disease until the severity of motor symptoms results in functional impairment. Therefore, the initiation of symptomatic treatment is considered an early indicator of disease progression in Parkinson’s disease and is used as an important benchmark in clinical trials.
Sotirios A. Parashos, M.D., Ph.D., of the Struthers Parkinson’s Center, Golden Valley, Minn., and colleagues in the NET-PD Investigators group analyzed data from 413 patients with early, untreated Parkinson’s disease who participated in two double-blind trials of experimental drugs.
After 12 months, the researchers assessed all the treatment groups to identify which patients had started taking medication for their symptoms-including levodopa or dopamine agonists, treatments that regulate the amount of the neurotransmitter dopamine. At this time, 200 of the 413 participants (48.5 percent) had started symptomatic treatment. Those who had higher levels of impairment and disability at the beginning of the study, as measured by several Parkinson’s disease scales, were more likely to progress quickly.
“Emotional, psychiatric and quality of life factors at baseline played a smaller role in determining need for symptomatic treatment and did not enter the final model when baseline impairment, disability and education were taken into account,” they conclude. “The impact of the patient’s education level on clinical management is an unexpected finding and merits further investigation.”
Source: Archives of Neurology, USA