Link between metabolism and breast cancer

NIH scientists identify molecular link between metabolism and breast cancer – A protein associated with conditions of metabolic imbalance, such as diabetes and obesity, may play a role in the development of aggressive forms of breast cancer, according to new findings by researchers at the National Cancer Institute (NCI).

Breast cancer’s genetic causes provide clues for new therapeutic targets

UNC Lineberger scientists lead cancer genome analysis of breast cancer — Team identifies genetic causes and similarity to ovarian cancer – The researchers, including a large group from the University of North Carolina at Chapel Hill, reported their study about genetic characterization of 800 breast tumors, finding some of the genetic causes of the most common forms of breast cancer, providing clues for new therapeutic targets, and identifying a molecular similarity between one sub-type of breast cancer and ovarian cancer.

Autism in children linked to Father’s Age

deCODE Genetics Study Finds Father?s Age?Not Mother?s Critical to New Mutations Passed to Offspring — Nature Published Study Signals Rise in Autism Spectrum Disorder May Be Partially Tied to Increasing Age of Fathers at Time When Children are Conceived – deCODE Genetics, a global leader in analyzing and understanding the human genome, in collaboration with Illumina, a global leader in the making of instruments to analyze the genome, reported in the journal Nature that a father?s age, not a mother?s, at the time a child is conceived is the single largest contributor to the passing of new hereditary mutations to offspring.

Colon cancer and rectal tumor constitute a single type of cancer

Study shows colon and rectal tumors constitute a single type of cancer — The Cancer Genome Atlas generates genomic data for colon and rectal cancers that point to potential targets for treatment – The pattern of genomic alterations in colon and rectal tissues is the same regardless of anatomic location or origin within the colon or the rectum, leading researchers to conclude that these two cancer types can be grouped as one, according to The Cancer Genome Atlas (TCGA) project’s large-scale study of colon and rectal cancer tissue specimens.

Bird flu may be possible from human to human through air

Avian flu viruses which are transmissible between humans could evolve in nature — Research provides insight into feasibility of virus becoming airborne transmissible – It might be possible for human-to-human airborne transmissible avian H5N1 influenza viruses to evolve in nature, new research has found. The findings, from research led by Professor Derek Smith and Dr Colin Russell at the University of Cambridge, were published today, 22 June in the journal Science.

Largest human cancer genome data released in US

World’s largest release of comprehensive human cancer genome data helps speed discoveries — Whole genome data from hundreds of St. Jude Children’s Research Hospital patients exceeds volume of all other sources combined – A comprehensive human cancer genome data is released in US for free access by the global scientific community. The amount of information released more than doubles the volume of high-coverage, whole genome data currently available from all human genome sources combined.

Violence during childhood may impact kids’ DNA

Violence puts wear and tear on kids’ DNA — Exposure to Violence During Childhood is Associated with Telomere Erosion from 5 to 10 Years of Age – Children who have experienced violence might really be older than their years. The DNA of 10-year-olds who experienced violence in their young lives has been found to show wear and tear normally associated with aging, a Duke University study has found.

Whole genome breast cancer study launched by Mayo Clinic USA

Mayo Clinic launches whole genome breast cancer study – The Breast Cancer Genome Guided Therapy Study (BEAUTY Project) will help physicians tailor chemotherapy to breast cancer patients based on their individual genomes and the genomes of their tumors.

Genetic changes in 3 genes linked to autism spectrum disorders

Mutations in 3 genes linked to autism spectrum disorders – Mutations in three new genes have been linked to autism, according to new studies including one with investigators at Mount Sinai School of Medicine. All three studies include lead investigators of the Autism Sequencing Consortium (ASC).

Cancer treatment with personalised approach to cancer patients

The path to personalized cancer treatment — Researchers identify genetic markers of drug sensitivity in cancer cells – Recently researchers have profiled genetic changes in cancer with drug sensitivity in order to develop a personalised approach to cancer treatments. They uncovered hundreds of associations between mutations in cancer genes and sensitivity to anticancer drugs.