Melanoma skin cancer triggered by BRAF gene mutation

Up to 70 per cent of melanoma skin cancers could be triggered by a particular genetic mutation, according to a study by The Institute of Cancer Research (ICR) published in Cancer.

The ICR scientists had previously found that the BRAF gene is damaged or mutated in up to 70 per cent of human melanoma, but they did not know whether this was a cause or result of the cancer.

Now, the same group of researchers has discovered that acquiring the BRAF mutation can be the first event in the cascade of genetic changes that eventually leads to melanoma ? the most deadly form of skin cancer.

This research, funded by Cancer Research UK, confirms that BRAF is a driving force behind the disease and could be the trigger that leads to skin cancer.

Lead author Professor Richard Marais from the ICR, said: “We know that excessive sun exposure is the main cause of skin cancer, but not much is known about the genetics behind it.

“Our study shows that the genetic damage of BRAF is the first step in skin cancer development.

“Understanding this process will help us develop more effective treatments for the disease.”

There are around 9,500 new cases of malignant melanoma and more than 2,300 deaths from the disease each year in the UK.

Over-exposure to sunlight causes at least two thirds of all malignant melanomas and up to nine out of ten of all non-melanoma skin cancers.

This excessive exposure damages DNA and causes genetic mutations.

Dr Lesley Walker, Director of Cancer Information at Cancer Research UK, said: “Skin cancer is the seventh most common cancer in the UK, but relatively little is known about the genetics behind the disease.

“This week, Cancer Research UK launches our SunSmart campaign to help raise awareness of the risks and causes of skin cancer.

“There’s lots of exciting research focused on developing new therapies that will block the function of mutant BRAF.

“A better understanding of the genetics of skin cancer can help scientists develop more targeted drugs with fewer side effects to treat the disease.”

Reference – Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice; Cancer Cell, Volume 15, Issue 4, 294-303, 7 April 2009

Source: Institute of Cancer Research, UK



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