273 human proteins required for HIV propagation

Using a technique called RNA interference to screen thousands of genes, researchers identified 273 human proteins required for HIV propagation. The vast majority had not been connected to the virus by previous studies. – Current drugs attack HIV itself, leaving patients vulnerable to counterattack by the rapidly mutating virus, which often evolves resistance. But the human proteins exploited by HIV represent potential therapeutic targets that could avoid this problem. The challenge will be to develop drugs that inhibit HIV by interacting with these human proteins without hurting our cells.

Oral osteoporosis medicines safe during dental work

Contrary to recent reports, oral osteoporosis medications that inhibit bone breakdown reduce the risk of jaw problems, based on an analysis of medical claims. – Some doctors and dentists had advised patients who take oral osteoporosis medications such as Fosamax and Boniva to postpone dental work, fearing that tooth extractions and other procedures would exacerbate jaw problems purportedly linked to the medication. But the new findings refute the link and suggest the benefits of dentistry likely outweigh the risks for many of these patients.

RNA may stop breast cancer spread

The identification of molecules that inhibit a cell’s metastatic potential may help guide clinical decision-making in the future by enabling oncologists to more accurately identify patients at highest risk for metastatic relapse. – Now, researchers can develop more effective drugs to prevent or treat cancer metastasis, as they have identified a specific group of microRNA molecules that are responsible for controlling genes that cause breast cancer metastasis.

Weight loss caused by chewing gum – BMJ

Sorbitol intake should be considered in patients with bowel problems, chronic diarrhoea, and weight loss. – Severe weight loss was detected in patients due to chronic diarrhea after eating chewing gum and sweets because of excess sorbitol intake, a widely used sweetener in “sugar-free” products. Sorbitol has laxative properties and is poorly absorbed by the small intestine.

Don’t postpone knee-replacement surgery

Osteoarthritis of the knee is the most common cause of disability among Americans. It’s a disease of age that affects more women than men on a 60-40 basis. – Research at the University of Delaware indicates that women wait longer to pursue knee-replacement surgery than men do.

Combined with exercise, cholesterol increase muscles

If you?re worried about high cholesterol levels and keeping heart-healthy as you get older, don?t push aside bacon and eggs just yet. A new study says they might actually provide a benefit. – Combined with exercise, cholesterol appears to play a role in contributing to muscle gain. Surprise – cholesterol may actually pose benefits, study shows.

Protein may trigger insulin production in diabetic patients

University of Florida researchers have coaxed liver and pancreatic cells within diabetic mice into churning out insulin by injecting the animals with a naturally occurring protein called Pdx1, opening up a new research avenue that someday could lead to safer treatments for type 1 diabetes. Pdx1 activates the genes controlling the development of the pancreas cells that make and release insulin to maintain safe levels of glucose in the body. – If the human body were a stage, then proteins would rank among the lead actors in the play we call “Life.” These large biological molecules hold many starring roles, and their lines are dictated by information encoded in our genes. They are production powerhouses, regulating the basic processes of living and controlling countless functions. Many are enzymes that produce or use energy. Others regulate genes.

Compstatin – new drug for vision loss, macular degeneration

UF scientists are testing the safety of experimental drug Compstatin for vision loss in macular degeneration patients. – University of Florida UF scientists are testing the safety of experimental drug Compstatin for vision loss in macular degeneration patients. In a first-of-its-kind safety research study, University of Florida researchers have injected an anti-inflammatory compound into the eye of a person with a sight-robbing disease.

Infants with birthmarks received less oxygen in womb

Evaluation of the placenta provides some important insights into pathophysiologic changes that take place during the prenatal and intrapartum process. – A hemangioma is a benign tumor of cells that line blood vessels, appearing during the first few weeks of life as a large birthmark or lesion. A study published in Pediatric Dermatology reveals that a disturbance of oxygen depletion was found in placentas of babies who developed infantile hemangioma (IH).

New ultrasound technique sharpens view of liver tumors

A high-energy form of ultrasound imaging developed by researchers at Duke University’s Pratt School of Engineering produces pictures of liver tumors that are better than those made with traditional ultrasound. – A new high-energy form of ultrasound imaging developed by researchers at Duke University’s Pratt School of Engineering produces pictures of liver tumors that are better than those made with traditional ultrasound, according to results of a clinical study.

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