Genes Archives

Genetic testing can gauge prostate cancer risk

Five genetic variants and a family history accounted for almost half (46 percent) of prostate cancer patients. Researchers identified five genetic locations associated with risk of developing prostate cancer: three on chromosome 8q24, one on chromosome 17q12 and one on 17q24.3. – Genetic testing of DNA in a blood sample can determine which men are likely to develop prostate cancer, as five genetic variants previously associated with prostate cancer risk have a strong cumulative effect.

273 human proteins required for HIV propagation

Using a technique called RNA interference to screen thousands of genes, researchers identified 273 human proteins required for HIV propagation. The vast majority had not been connected to the virus by previous studies. – Current drugs attack HIV itself, leaving patients vulnerable to counterattack by the rapidly mutating virus, which often evolves resistance. But the human proteins exploited by HIV represent potential therapeutic targets that could avoid this problem. The challenge will be to develop drugs that inhibit HIV by interacting with these human proteins without hurting our cells.

RNA may stop breast cancer spread

The identification of molecules that inhibit a cell’s metastatic potential may help guide clinical decision-making in the future by enabling oncologists to more accurately identify patients at highest risk for metastatic relapse. – Now, researchers can develop more effective drugs to prevent or treat cancer metastasis, as they have identified a specific group of microRNA molecules that are responsible for controlling genes that cause breast cancer metastasis.

Protein may trigger insulin production in diabetic patients

University of Florida researchers have coaxed liver and pancreatic cells within diabetic mice into churning out insulin by injecting the animals with a naturally occurring protein called Pdx1, opening up a new research avenue that someday could lead to safer treatments for type 1 diabetes. Pdx1 activates the genes controlling the development of the pancreas cells that make and release insulin to maintain safe levels of glucose in the body. – If the human body were a stage, then proteins would rank among the lead actors in the play we call “Life.” These large biological molecules hold many starring roles, and their lines are dictated by information encoded in our genes. They are production powerhouses, regulating the basic processes of living and controlling countless functions. Many are enzymes that produce or use energy. Others regulate genes.

Lung cancer cells’ survival gene 14-3-3zeta seen as drug target

Lung cancer cells’ survival gene 14-3-3zeta seen as drug target, as lung cancer cells can?t survive on their own when this key gene called 14-3-3zeta is silenced. – One of the deadliest forms of cancer appears to carry a specific weakness. When a key gene called 14-3-3zeta is silenced, lung cancer cells can’t survive on their own, researchers have found.

Novel anti-cancer strategy moves to clinic

Emory University researchers have developed a novel anti-tumor compound that represents a distinct strategy: targeting one of the most important “intercept points” for cancer cells. – Researchers at Emory University have developed a novel anti-tumor compound that represents a distinct strategy: targeting one of the most important “intercept points” for cancer cells.

New strategies work to put cancer on the firing line

Cancer cells are our own cells gone awry. That means our immune system doesn?t always see cancer as a horrific invader. – Dr. Yukai He wants to put cancer in the bull’s eye. “Cancer really comes from us,” the Medical College of Georgia Cancer Center immunologist says of the scary reality that cancer cells are our own cells gone awry. That means our immune system doesn’t always see cancer as a horrific invader.

Mouth rinse gargle test for cancer

A simple mouth rinse may provide a new way to screen for head and neck cancers in people at high risk for these diseases. – A morning gargle could someday be more than a breath freshener ? it could spot head and neck cancer, say scientists at the Johns Hopkins Kimmel Cancer Center. Their new study of a mouth rinse that captures genetic signatures common to the disease holds promise for screening those at high risk, including heavy smokers and alcohol drinkers.

Potential drugs for mental retardation and autism treatment

US researchers say they have successfully corrected key symptoms of a type of autism and mental retardation in mice, a development which could offer sufferers a potential treatment. – Researchers at MIT’s Picower Institute for Learning and Memory have corrected key symptoms of mental retardation and autism in mice. The work, which will be reported in the Dec. 20 issue of Neuron, indicates that a certain class of drugs could have the same effect in humans. These drugs are not yet approved by the FDA, but will soon be entering into clinical trials.

Late developmental growth may risk depression

Children with low weight during infancy or slight developmental delays may be at greater risk for developing depression.
– Psychiatrists remain divided as to how to define and classify the mood and anxiety disorders, the most common mental disorders. Committees across the globe are currently pondering how best to carve nature at its anxious joints for the fifth version of the Diagnostic and Statistical Manual (DSM-V), the “gold standard” reference book for psychiatrists.

Sickle cell anemia treated with stem cells

Using a new type of stem cells made from ordinary skin cells, US researchers said they treated mice with sickle cell anemia.
– MIT researchers have successfully treated mice with sickle-cell anemia in a process that begins by directly reprogramming the mice’s own cells to an embryonic-stem-cell-like state, without the use of eggs.

Gene identified that influences alcohol consumption

Researchers applied a variety of genetic and analytic techniques to identify a chromosomal region, and ultimately a gene, associated with alcohol preference.
– A variant of a gene involved in communication among brain cells has a direct influence on alcohol consumption in mice, according to a new study by scientists supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH), and the U.S. Army.