CD16 monocyte could be a biomarker for progression of HIV

Expansion of a monocyte subset in HIV patients could serve as a biomarker for progression of the disease. – An increase in the CD163+/CD16+ monocyte subset could be a biomarker for the progression of HIV disease, according to researchers at Temple University, reported in the March issue of AIDS Research and Human Retroviruses.

Genetic errors may cause schizophrenia

A team of researchers at the University of Washington and Cold Spring Harbor Laboratories has uncovered genetic errors that may shed light on the causes of schizophrenia. The scientists found that deletions and duplications of DNA are more common in people with the mental disorder, and that many of those errors occur in genes related to brain development and neurological function. – Schizophrenia, a debilitating psychiatric disorder, is caused by some genetic errors due to deletions and duplications of DNA are more common in people with the mental disorders, revealed by researchers at the University of Washington and Cold Spring Harbor Laboratories.

Past child abuse and genes result in PTSD risk for adults

A traumatic event is much more likely to result in posttraumatic stress disorder (PTSD) in adults who experienced trauma in childhood ? but certain gene variations raise the risk considerably. – A traumatic event is much more likely to result in posttraumatic stress disorder (PTSD) in adults who experienced trauma in childhood ? but certain gene variations raise the risk considerably if the childhood trauma involved physical or sexual abuse, scientists have found. The research was conducted with funding from the National Institute of Mental Health, which is part of the National Institutes of Health, and others.

Protein Robo4 may reverse macular degeneration, diabetic retinopathy

Two major eye diseases and leading causes of blindness?age-related macular degeneration and diabetic retinopathy?can be reversed or even prevented by drugs that activate a protein found in blood vessel cells. – Two major eye diseases and leading causes of blindness-age-related macular degeneration and diabetic retinopathy-can be reversed or even prevented by drugs that activate a protein found in blood vessel cells, researchers at the University of Utah School of Medicine and several other institutions have announced in a new study.

Conservation of genes may stop aging

This report describes the identification of conserved aging-related genes in simple model organisms that may lead to the characterization of similar genes playing a role in human aging and age-associated diseases. – A study published online in Genome Research provides new insight into the evolutionary conservation of the genes and pathways associated with aging. This report describes the identification of conserved aging-related genes in simple model organisms that may lead to the characterization of similar genes playing a role in human aging and age-associated diseases.

Gene mutations may extend human life span

Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found. – Mutations in genes governing an important cell-signaling pathway influence human longevity, scientists at the Albert Einstein College of Medicine of Yeshiva University have found. Their research is described in the March 4 issue of the Proceedings of the National Academy of Sciences.

Genes involved in inflammation may hold clue to age-related macular degeneration

A University of Southampton research team, led by Professor Andrew Lotery, has identified a new genetic risk factor for age-related macular degeneration (AMD), a major cause of untreatable blindness in elderly people in developed countries. – A University of Southampton research team, led by Professor Andrew Lotery, has identified a new genetic risk factor for age-related macular degeneration (AMD), a major cause of untreatable blindness in elderly people in developed countries.

Zebrafish offer useful screening tool for genes, drugs that protect against hearing loss

A small striped fish is helping scientists understand what makes people susceptible to a common form of hearing loss, although, in this case, it?s not the fish?s ears that are of interest. – A small striped fish is helping scientists understand what makes people susceptible to a common form of hearing loss, although, in this case, it’s not the fish’s ears that are of interest. In a study published in the Feb. 29 issue of the journal PLoS Genetics, researchers at the University of Washington have developed a research method that relies on a zebrafish’s lateral line-the faint line running down each side of a fish that enables it to sense its surroundings-to quickly screen for genes and chemical compounds that protect against hearing loss from some medications.

Race differences affect response to drugs and infections

Gene expression differences between those of European and African ancestry affect response to drugs and infections. – Differences in gene expression levels between people of European versus African ancestry can affect how each group responds to certain drugs or fights off specific infections, report researchers from the University of Chicago Medical Center and the Expression Research Laboratory at Affymetrix Inc. of Santa Clara, CA.

Researchers identify protein that fuels ovarian cancer

Researchers identify protein that fuels ovarian cancer, but its production can be stifled by a tiny bit of RNA wrapped in a fatty nanoparticle. – A protein that stimulates blood vessel growth worsens ovarian cancer, but its production can be stifled by a tiny bit of RNA wrapped in a fatty nanoparticle, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in the Journal of the National Cancer Institute.

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