Genome

Genome is the total genetic content contained in a haploid set of chromosomes in eukaryotes, in a single chromosome in bacteria, or in the DNA or RNA of viruses.

Novel antimalarial drug candidate identified

New antimalarial drug candidate with novel mechanism of action has the potential to rapidly clear a Plasmodium infection upon administration of a single oral dose, as published in Science – Novartis announced that scientists at the Novartis Institute for Tropical Diseases (NITD), in collaboration with researchers from the Genomics Institute of the Novartis Research Foundation (GNF), the Swiss Tropical and Public Health Institute and The Scripps Research Institute have discovered a novel compound that shows promise as a next generation treatment for drug resistant malaria.

New genomic marker for tuberculosis

New genomic marker for tuberculosis may help identify patients who will develop the disease — Study highlights how blood profiling techniques could change patient care – It may soon be possible to identify patients who will develop tuberculosis, as scientists have identified changes in the blood specific to the disease.

Genetic variant linked to common migraine

First genetic link to common migraine exposed — Genetic variant may increase susceptibility to migraine triggers – Researchers have produced new insights into the triggers for migraines attacks. They have identified the first-ever genetic risk factor associated with common types of migraine.

New Parkinson’s gene is linked to immune system

New Parkinson’s gene is linked to immune system – A hunt throughout the human genome for variants associated with common, late-onset Parkinson’s disease has revealed a new genetic link that implicates the immune system and offers new targets for drug development.

Cigarette smoke causes harmful changes in lungs even at lowest levels

Cigarette smoke causes harmful changes in the lungs even at the lowest levels — First study to show alteration in the function of genes in the lungs resulting from secondhand and low-level smoking – Casual smokers may think that smoking a few cigarettes a week is “no big deal.” But according to new research from physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, having an infrequent smoke, or being exposed to secondhand smoke, may be doing more harm than people may think.

95 genetic variants linked to cholesterol, triglycerides

Scientists identify 95 genetic variants associated with cholesterol, triglycerides – Researchers have discovered or confirmed 95 regions of the human genome where genetic variants are associated with blood cholesterol and triglyceride levels, which are major indicators of heart disease risk.

Brain imaging findings in Alzheimer’s disease associated with genetic factors

Study evaluates association of genetic factors and brain imaging findings in Alzheimer’s disease – By investigating the association between genetic loci related to Alzheimer’s disease and neuroimaging measures related to disease risk, researchers may have uncovered additional evidence that several previously studied genetic variants are associated with the development and progression of Alzheimer’s disease and also may have identified new genetic risk factors for further study, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals.

Genetic variants may make people susceptible to autism disorder

Autism genome project identifies genetic variants that may make people susceptible to disorder – Autism is caused in part by rare genetic changes called copy number variants (CNVs), revealed by an international consortium of researchers from more than 70 universities, including the University of Utah.

Pesticides, chemicals, vitamin E linked to diabetes

New associations between diabetes, environmental factors found by novel Stanford analytic technique – Researchers at the Stanford University School of Medicine suggests that one should begin looking suspiciously at other aspects of life – like past exposure to certain pesticides or chemicals and even one form of vitamin E. This may lead to diabetes.

New gene linked to Alzheimer’s disease

New gene associated with increased risk of Alzheimer’s disease – Researchers have identified a gene that appears to increase a person’s risk of developing late-onset Alzheimer’s disease, the most common type of Alzheimer’s disease.