Obesity and metabolic syndrome associated with impaired brain function in adolescents – Metabolic syndrome (MetS) is associated with cognitive and brain impairments in adolescents and calls for pediatricians to take this into account when considering the early treatment of childhood obesity. As childhood obesity has increased in the U.S., so has the prevalence of metabolic syndrome ? a constellation of three or more of five defined health problems, including abdominal obesity, low HDL (good cholesterol), high triglycerides, high blood pressure and pre-diabetic insulin resistance.